Antifilarial activity of Zoanthus species (Phylum Coelenterata, Class Anthzoa) against human lymphatic filaria, Brugia malayi.
Identifieur interne : 008860 ( Main/Exploration ); précédent : 008859; suivant : 008861Antifilarial activity of Zoanthus species (Phylum Coelenterata, Class Anthzoa) against human lymphatic filaria, Brugia malayi.
Auteurs : V. Lakshmi [Inde] ; A. Saxena ; K. Pandey ; Preeti Bajpai ; Shailja Misra-BhattacharyaSource :
- Parasitology research [ 0932-0113 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Brugia malayi (), Brugia malayi (physiologie), Cnidaria (), Extraits tissulaires (), Extraits tissulaires (pharmacologie), Extraits tissulaires (usage thérapeutique), Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Fractionnement chimique, Humains, Modèles animaux de maladie humaine, Muridae (parasitologie), Relation dose-effet des médicaments.
- MESH :
- parasitologie : Muridae.
- pharmacologie : Extraits tissulaires, Filaricides.
- physiologie : Brugia malayi.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Extraits tissulaires, Filaricides.
- Animaux, Brugia malayi, Cnidaria, Extraits tissulaires, Fractionnement chimique, Humains, Modèles animaux de maladie humaine, Relation dose-effet des médicaments.
English descriptors
- KwdEn :
- Animals, Brugia malayi (drug effects), Brugia malayi (physiology), Chemical Fractionation, Cnidaria (chemistry), Disease Models, Animal, Dose-Response Relationship, Drug, Elephantiasis, Filarial (drug therapy), Filaricides (pharmacology), Filaricides (therapeutic use), Humans, Muridae (parasitology), Tissue Extracts (chemistry), Tissue Extracts (pharmacology), Tissue Extracts (therapeutic use).
- MESH :
- chemical , chemistry : Tissue Extracts.
- chemical , pharmacology : Filaricides, Tissue Extracts.
- chemistry : Cnidaria.
- drug effects : Brugia malayi.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Muridae.
- physiology : Brugia malayi.
- chemical , therapeutic use : Filaricides, Tissue Extracts.
- Animals, Chemical Fractionation, Disease Models, Animal, Dose-Response Relationship, Drug, Humans.
Abstract
The chloroform methanol (1:1) extract of an unidentified green zoanthus (Phylum Coelenterata, Class Anthozoa) showed promising in vitro adulticidal activity with a lethal concentration of 125 microg/ml on Brugia malayi. This extract brought about a 52.2% reduction in circulating microfilariae of B. malayi when administered to infected Mastomys coucha at 250 mg/kg, orally for 5 consecutive days. Further fractionation of the extract led to the recovery of four fractions, which were evaluated simultaneously in both in vitro and in vivo systems against B. malayi. The chloroform fraction at 250 mg/kg orally for 5 days exhibited the highest macrofilaricidal action (42.5%), closely followed by the insoluble n-butanol fraction (34.3%), the soluble hexane fraction (32.4%), and the soluble n-butanol fraction (20.4%). In addition, the hexane soluble fraction caused 44.3% sterilization of the surviving female parasites. Two compounds isolated were found devoid of antifilarial activity.
DOI: 10.1007/s00436-004-1124-6
PubMed: 15258853
Affiliations:
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This extract brought about a 52.2% reduction in circulating microfilariae of B. malayi when administered to infected Mastomys coucha at 250 mg/kg, orally for 5 consecutive days. Further fractionation of the extract led to the recovery of four fractions, which were evaluated simultaneously in both in vitro and in vivo systems against B. malayi. The chloroform fraction at 250 mg/kg orally for 5 days exhibited the highest macrofilaricidal action (42.5%), closely followed by the insoluble n-butanol fraction (34.3%), the soluble hexane fraction (32.4%), and the soluble n-butanol fraction (20.4%). In addition, the hexane soluble fraction caused 44.3% sterilization of the surviving female parasites. Two compounds isolated were found devoid of antifilarial activity.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Bajpai, Preeti" sort="Bajpai, Preeti" uniqKey="Bajpai P" first="Preeti" last="Bajpai">Preeti Bajpai</name><name sortKey="Misra Bhattacharya, Shailja" sort="Misra Bhattacharya, Shailja" uniqKey="Misra Bhattacharya S" first="Shailja" last="Misra-Bhattacharya">Shailja Misra-Bhattacharya</name><name sortKey="Pandey, K" sort="Pandey, K" uniqKey="Pandey K" first="K" last="Pandey">K. Pandey</name><name sortKey="Saxena, A" sort="Saxena, A" uniqKey="Saxena A" first="A" last="Saxena">A. Saxena</name></noCountry><country name="Inde"><noRegion><name sortKey="Lakshmi, V" sort="Lakshmi, V" uniqKey="Lakshmi V" first="V" last="Lakshmi">V. Lakshmi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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